The White House will issue a blueprint that represents “the most comprehensive plan to tackle prescription drug affordability of any president,” a senior official told journalists on Thursday night.

Asked if the plan would include direct negotiations by Medicare, the official said, “No, we are talking about something different.”

“We are not calling for Medicare negotiation in the way that Democrats have called for,” the official said later. “We clearly want to make important changes that will dramatically improve the way negotiation takes place inside the Medicare program.”