Six states are down to only one abortion clinic; by the end of this week, Missouri could have zero. Some women seeking abortions have to travel long distances, and face mandatory waiting periods or examinations. On top of that, a new wave of restrictive laws, or outright bans, is rippling across GOP-led states like Alabama and Georgia…

Years of piecemeal state laws have left their mark. Mandatory waiting periods, travel, missed work and lost wages all make getting an abortion more expensive and more difficult, particularly for low-income women. Doctors and clinic staff have to face protesters, threats, proliferating regulations and draining legal challenges; clinics have closed. In remote parts of the midwest and south, women may have to travel more than 300 miles to end a pregnancy.

“This is a moment of seeing how all of these laws fly in the face of medicine and science and go against what we in the medical profession know, which is that any restriction on medical care by politicians will endanger people’s health,” Planned Parenthood President Leana Wen, a physician herself, said in an interview.