Democratic Congressional Campaign Committee Chairman Steve Israel (D-N.Y.) has already identified 16 GOP House members he calls “the out-of-touch caucus,” who he will try to paint as extreme on abortion and a host of other issues. Fifteen of the 16 lawmakers–all of whom are male–voted last month for a proposal to ban abortions 20 weeks after fertilization. (The one exception is Rep. Joe Runyan (N.J.), who voted to defund Planned Parenthood in the last Congress.) Most of them are from moderate suburban districts that President Obama won or came close to winning.

In addition to Runyan, the other lawmakers hailing from districts Obama won in 2012 include Reps. Mike Coffman (Colo.), Chris Gibson (N.Y.), Michael Grimm (N.Y.), Joe Heck (Nev.), John Kline (Minn.), Frank Lobiondo (N.J.), Gary G. Miller (Calif.), Erik Paulsen (Minn.), Scott Rigell (Va.) and Bill Young (Fla.)

The House Republicans who represent districts where Mitt Romney beat Obama by less than two points include Michael Fitzpatrick (Penn.), Scott Garrett (N.J.), Pat Meehan (Penn.) and Frank Wolf (Va.) The final target is Kerry Bentivolio (Mich.), who won reelection by less than seven points.

Many of these lawmakers have fought back serious challenges before, including Kline, Garrett, Wolf and Young. But others, who have served shorter terms in Congress, could face a barrage of activism and advertising on the issue.