The statement from the National Security Commission said that, at 8:52 Saturday evening, surveillance cameras at the Altiplano federal prison saw Guzman approaching a shower area in which prisoners also wash their belongings.
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When Guzman was not seen again for some time, officials checked his cell, found it empty, and issued an alert.
Altiplano is a maximum security prison in south central Mexico.
Officials not only launched a manhunt, they also closed Toluca International Airport, a 45-minute drive away.
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