The statement from the National Security Commission said that, at 8:52 Saturday evening, surveillance cameras at the Altiplano federal prison saw Guzman approaching a shower area in which prisoners also wash their belongings.
When Guzman was not seen again for some time, officials checked his cell, found it empty, and issued an alert.
Altiplano is a maximum security prison in south central Mexico.
Officials not only launched a manhunt, they also closed Toluca International Airport, a 45-minute drive away.
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