After the Chamber backed nearly two dozen freshman House Democrats for reelection last year, House Minority Leader Kevin McCarthy told Fox News he didn’t want the Chamber’s endorsement “because they have sold out.”

Senate Minority Leader Mitch McConnell told POLITICO last year that he thought the Chamber was “so confused about what they’re about that they probably don’t make much difference.”

Josh Holmes, McConnell’s former chief of staff and a close ally, called some of the Chamber’s recent positions “totally unmoored to any sort of advocacy for business whatsoever.”

The Tanden endorsement, he said, “is particularly mysterious to me, because she has personally participated in multiple efforts during the Obama years to basically destroy Tom Donohue, and the U.S. Chamber for opposing Obamacare, and for opposing them in elections in 2014 and 2012.”