Why it matters: The new Senate political math could dash the ambitions of some Democrats, including those who have clashed with Republicans.

It could push Biden to go with more centrist options, like Lael Brainard for Treasury or Tony Blinken for State, sources tell Axios.

Susan Rice and Stacey Abrams could be early casualties, depending on McConnell’s posture.

But it could also open paths for others, like Sen. Chris Coons, who could benefit from a tradition of senatorial courtesy for quick confirmations of nominees within its ranks.

A source close to McConnell tells Axios a Republican Senate would work with Biden on centrist nominees but no “radical progressives” or ones who are controversial with conservatives.