Nationwide, 77,640 new cases were reported for the day, up from the previous record of 75,723 on July 29, according to the latest tally compiled by NBC News.
The record-breaking daily tally comes as the total number of coronavirus cases in the country has reached nearly 8.5 million, with 224,280 deaths. There were 921 coronavirus-related deaths reported on Thursday.
Public health officials warned this week that the number of cases is rising across most of the country.
Dr. Jay Butler, deputy director for infectious diseases at the Centers for Disease Control and Prevention, said Wednesday afternoon that the agency has noted a “distressing trend” in which coronavirus case numbers are “increasing in nearly 75 percent of the country.”