As many as 75,000 Americans could die because of drug or alcohol misuse and suicide as a result of the coronavirus pandemic, according to an analysis conducted by the national public health group Well Being Trust.

The group is sounding the alarm that the growing unemployment crisis, economic downturns and stress caused by isolation and lack of a definitive end date for the pandemic could significantly increase so-called “deaths of despair” unless local, state and federal authorities take action.

“Unless we get comprehensive federal, state, and local resources behind improving access to high quality mental health treatments and community supports, I worry we’re likely to see things get far worse when it comes to substance misuse and suicide,” Well Being Trust’s chief strategy officer Dr. Benjamin F. Miller told CNN.