The U.S. topped 1,000 coronavirus deaths in a single day for the first time Wednesday, a daily death toll more than double that of two of America’s most deadly illnesses – lung cancer and the flu.

Death counts from the virus are difficult to keep up to date, but the Johns Hopkins coronavirus database – whose sources include the World Health Organization, the U.S. Centers for Disease Control and Prevention, the European CDC and the National Health Commission of China – shows that the U.S. hit 1,040 cases Wednesday at 10:25 p.m. ET. Since the virus’ first appearance in the U.S. in late January, 5,116 people have died and more than 215,000 have been infected.

The previous high mark for a single day in the U.S. was Tuesday, with 504 deaths.

Some researchers say the daily death toll could more than double – to 2,200 or more – by mid-April. That figure would eclipse heart disease, the nation’s No. 1 killer with about 1,772 deaths per day, according to the CDC.