There are two primary dangers of a universal DNA database. First, as Christine Rosen once wrote, DNA “provides an inescapable means of identification, categorization, and profiling” that is uniquely revelatory:

“…DNA is a person’s ‘future diary.’ It provides genetic information unique to each person; it has the potential to reveal to third parties a person’s predisposition to illnesses or behaviors without the person’s knowledge; and it is permanent information, deeply personal, with predictive powers. Taken together, the coming age of DNA technology will change the character of human life, both for better and for worse, in ways that we are only beginning to imagine — both because of what it will tell us for certain and what it will make us believe. To know one’s own future diary — or to know someone else’s — is to call into question the very meaning and possibility of human liberty.”

Second, imagine a permanent database of information that powerful. How long do you anticipate that trove would exist before being breached by nefarious actors? My assumption is that all permanent databases of sufficient size and value will be hacked eventually—and sooner, rather than later, when the security infrastructure is designed and maintained by IT bureaucrats in state governments.