The multimillion-dollar plan of advertising and grass-roots activism will focus heavily on convincing two Republican defenders of the ACA, Sens. Lisa Murkowski (Alaska) and Susan Collins (Maine), to buck the president again by denying his first choice to replace retiring Justice Anthony M. Kennedy. Trump plans to reveal his selection Monday.

One group, Demand Justice, plans to launch a $5 million campaign Thursday with ads in both senators’ states focused on the possibility that the next justice will provide the majority vote to allow states to ban abortion, overturning the 1973 decision in Roe v. Wade. NARAL Pro-Choice America announced plans Tuesday to take out full-page ads in four Maine newspapers highlighting the issue.

“We had a particular success with Murkowski and Collins, obviously, in the ACA fight,” said Brad Woodhouse, the executive director of Protect our Care, a liberal umbrella group that did organizing around the fights in 2017 over what had been President Barack Obama’s signature legislative achievement. “So we kind of understand how to do the work in those states.”