“Another day likely equals another concession. It’s time to walk away from the negotiating table and regain the upper hand,” Cotton said Wednesday.

“The longer the Obama administration stays at the negotiating table with Iran, the more concessions it makes,” said Sen. Ted Cruz (R-Texas), who questioned whether Iran can be forced to allow nuclear inspections before sanctions are lifted. “Enough is enough. The Obama administration’s bad deal is only getting worse with time.”

Other Republicans, frustrated by the blown deadlines, did not explicitly call for the talks to end but began to criticize the Obama administration after mostly holding their fire on Tuesday, when the first one-day negotiating extension was announced. By Wednesday, as the world learned that talks would spill into Thursday, many in the GOP had enough.