The only reason Khamenei’s regime is negotiating with Obama at all is because they want the world’s economic sanctions on Iran lifted. In return for lifting those sanctions, Iran is supposed to give up its ambitions for a nuclear weapon. That’s the basic outline of the deal: Iran gets the sanctions lifter and Obama gets an end to their nuclear weapons program.
But read the above Friedman paragraphs again. Obama’s Middle East strategy is premised on “transforming” the current Iranian government by ending sanctions on Iran. This means that Obama wants the sanctions on Iran lifted just as badly as Ayatollah Khamenei.
Now, granted, Obama and Khamenei have very different ideas about what the outcome of the end of sanctions will be. Obama believes an Iran without economic sanctions will lead to if not Kamanei’s demise, than it least the marginalization of him and his followers. Khamenei, on the other hand, believes an Iran without sanctions will allow his regime to strengthen their control over not just Iran, but also the entire Middle East.