Ruth Buzzi, who rose to fame as the frumpy and bitter Gladys Ormphby on the groundbreaking sketch comedy series “Rowan & Martin’s Laugh-In” and made over 200 television appearances during a 45-year career, has died at age 88.

Buzzi died Thursday at her home in Texas, her agent Mike Eisenstadt said. She had been diagnosed with Alzheimer’s and was in hospice care. Shortly before her death, her husband Kent Perkins, had posted a statement on Buzzi’s Facebook page, thanking her many fans and telling them: “She wants you to know she probably had more fun doing those shows than you had watching them.”

Buzzi won a Golden Globe and was a two-time Emmy nominee for the NBC show that ran from 1968 to 1973. She was the only regular to appear in all six seasons, including the pilot.

She was first spotted by “Laugh-In” creator and producer George Schlatter playing various characters on “The Steve Allen Comedy Hour.”