Although Amazon has already been hit by local antitrust suits in Washington, D.C. and California, the coming federal cases would be the most significant challenges to the global company yet. The exact timing of any cases or settlements is unknown.

POLITICO spoke to more than 10 people with direct knowledge of the investigations by the FTC’s competition and consumer protection teams to put together a comprehensive picture of how the agency is now pursuing Amazon, why it didn’t take action on the company’s most recent major acquisition of One Medical and what is likely to happen in the coming months.