Do COVID vaccine mandates make sense?

Visitors to the National Academy of Sciences (NAS) in Washington, D.C., receive a clear reminder that, 3 years after the World Health Organization (WHO) declared COVID-19 a pandemic on 10 March 2020, it’s far from over. Before entering, they must show a guard proof that they have been vaccinated against COVID-19. Such demands were common around the world a year ago, with wide support from infectious disease scientists and public health researchers. But by now, almost everyone has had natural infections with SARS-CoV-2 or been vaccinated against the coronavirus—sometimes both—and it’s become clear that vaccine-induced immunity quickly loses its ability to prevent infection and spread of the latest variants. Some now say the mandates are outdated.

The persistent requirements are “baffling to say the least,” says Heidi Larson, an anthropologist at the London School of Hygiene & Tropical Medicine and director of the Vaccine Confidence Project. She spoke at a major infectious disease meeting this year that required all attendees to show they had had two doses of a vaccine—with no need for a recent booster. “It’s not like it’s going to mitigate the spread.”

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