The unprecedented crisis at the southern border appears to be taking a toll on rank-and-file Customs and Border Protection (CBP) officers — with three agents taking their lives in November.

This brings the 2022 total suicides within the agency to 14, more than any year in over a decade, sources told The Post.

“It’s a very serious epidemic that’s happening within the agency,” said US Rep. Tony Gonzales (R-Texas), whose congressional district runs along the US-Mexico border from Del Rio to El Paso.

While there’s no single reason attributed for the spike in agent suicides, Gonzales feels the ongoing migrant crisis — with more than 2 million people crossing the border in the last year, hundreds of immigrant deaths, children arriving alone at border crossings, long work hours and dealing with high-stress situations — is taking its toll.