These latest shifts are often taking place in more solidly Democratic areas that have prided themselves on their pandemic response so far.

Driving the news: Colorado announced last week its intention to close 14 state-run testing and vaccination sites by the end of the month, and it ended a program to ship at-home rapid tests to residents.

That means definitive PCR tests and vaccines in the state — including boosters — will more often need to come from battle-weary health care providers moving forward.

New strategies are needed because vaccine demand is plummeting, ​​Colorado Department of Public Health and Environment spokesperson Kristen Stewart told Axios.