“I’m mad,” said Mabel De Beunza, a publicist in her early 40s who spent 90 minutes at a drive-through testing line in downtown Miami on Monday after experiencing cold symptoms. No matter what her test result, she has decided against seeing her mother, who is immunocompromised, on Christmas.

“We’ve done so much, and still have this,” said Ms. De Beunza, whose family is vaccinated and boosted. “It’s been such a rough year.”…

Conversations with more than two dozen people across the country revealed that, more than panicked, Americans are simply exhausted by the emotional pandemic roller coaster and confused by mixed messages from experts and leaders about appropriate precautions…

Hilton R. Raethel, president of the Healthcare Association of Hawaii, called the increase dramatic and blamed pandemic fatigue for the low rates of booster shots among residents. About 17 percent of fully vaccinated residents had received a booster as of Sunday, the second-lowest rate in the country.

“‘I’ve done so much for so long, I’m sort of reluctant to do any more,’” Mr. Raethel said, summarizing public sentiment.