A first step towards curing PTSD with a pill

Dr. Jennifer Perusini, founder of Neurovation Labs, says PTSD has a unique biomarker called GluA1. It’s a protein that is part of a glutamate receptor system, which helps memory formation. But trauma can also spur the creation of GluA1.

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In 2014, during experiments for her doctoral thesis, she found that rats subjected to traumatic experiences had more GluA1. They also experienced anxiety and symptoms associated with PTSD, even when they weren’t experiencing threatening noises and lights.

Blocking the protein removed the anxiety, but the rats still displayed a healthy reaction to new frightening stimuli. That’s key, because it’s important to retain the ability to be scared by actual threats.

Perusini is currently in pre-clinical trial mode for a medicine that can block GluA1, and the clinical trial process could take years. But she already has financial support from the Air Force and from the Army through the Army’s xTech program, which awarded her $145,000 to develop her model that targets the protein.

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