Harry Siegel: Let’s start with the big question: Why is it that you think COVID-19 isn’t going away, and does that mean the U.S. is in a bubble right now, as vaccines are being widely distributed here? Larry Brilliant: Boy, I wish we could reach herd immunity. But there’s a number of reasons why we can’t. First and foremost, a virus that infects multiple species, animals and humans, and a virus that has multiple new variants, each one having the potential to reinfect people, is sort of disqualified from being a candidate to be eradicated. Because in both cases, the denominator keeps changing, of how many people could be exposed to the disease. If you’re exposed to or get vaccinated against the disease and then a new variant comes in that can still infect you, the concept of herd immunity no longer really applies. And if animals—and we’ve got 12 different species who’ve been infected with COVID-19, usually from humans—if they can harbor it, and then infect humans, then you can’t eradicate the disease like we’ve been unable to eradicate yellow fever, because monkeys get it and they just don’t like to put their arms out to get vaccinated, and it’s really tough to get them to stand in line.