The seven-day average of new cases jumped to 57,695 Wednesday, 9.5% above the prior week, marking the biggest increase since Jan. 12, according to Johns Hopkins University data…

An almost 10% uptick should have states reconsidering reopening plans and trying to accelerate vaccination, focusing on the hardest-hit neighborhoods, Weisfuse said. Growing pandemic fatigue among younger Americans, especially those traveling for spring break, is a significant concern, because they’re less likely to have received shots…

Case declines in big states such as California, Texas and Florida have masked rises elsewhere. “We’re seeing a localized surge, but we could see it everywhere,” Mokdad said. “If we are not quick to dialing back or imposing mandates to slow down the surge, yes, we’re going to see a surge in cases.”