UK trial to mix and match COVID vaccines to try to improve potency

The trial will begin if the University of Oxford/AstraZeneca vaccine is approved in the coming weeks, as is hoped. The treatment can only be administered with licensed vaccines.

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The news comes as the first British patients begin receiving coronavirus vaccinations from Tuesday, a jab made by Pfizer/BioNTech, a week after the UK became the first country in the western world to approve a Covid vaccine.

Those who take part in January’s trial will get one shot of AstraZeneca’s vaccine and one of the Pfizer injection. A vaccine from US biotech firm Moderna will also be included if it gets approval…

The concept is known as a heterologous prime-boost. “It means mix and matching vaccines,” said Bingham. “So you do a prime with one vaccine and then the second – whether it’s 28 days or two months or whatever the agreed periods would be – would be with a different vaccine.”

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