“Owing to the imperfect blood-testes/deferens/epididymis barriers, SARS-CoV-2 might be seeded to the male reproductive tract, especially in the presence of systemic local inflammation,” the authors hypothesized.

A team of reproductive health specialists out of IRCCS Ospedale Policlinico San Martino and the University of Padova in Italy offered more ideas in a recent article published to the journal Andrology.

SARS-CoV-2 uses the ACE2 and TMPRSS2 enzymes to infect cells, and both of these enzymes are widespread in the testes, the male reproductive glands that produce sperm and testosterone. So the testes are an obvious target. These two enzymes are also present in the urinary tract, raising the potential that semen could pick up residual virus particles from an infection there during ejaculation. The prostate, a walnut-sized gland located between the bladder and the penis that produces the fluid medium for sperm in semen, could also provide a refuge for the coronavirus, the authors say.