Caylin Newton accounted for 330 total offensive yards and three touchdowns to lead 45-point underdog and FCS-member Howard to a stunning 43-40 win Saturday night in the season opener and debut for new Bison coach Mike London.

Howard spoiled the start of UNLV’s 50th season of play with the biggest upset in college football history based on point spread. Stanford held the previous record when it was declared a 40-point underdog against USC in 2007 and beat the Trojans.