Ossoff comes up short, his loss will deal a major blow to their newfound momentum and political activism.

The stakes are just as high for the GOP. If it loses the seat left open by Health and Human Services Secretary Tom Price, Trump will likely shoulder the blame and Republicans could start defecting from his agenda.

On the other hand, a victory for Republican Karen Handel will signify that opposition to Trump might not win Democrats the House in 2018.

In the final days of the race, Ossoff and Handel have sought to steer clear of national politics, with each candidate barely uttering Trump’s name. Both have also downplayed the national implications of the race, even though it has been a magnet for attention and tens of millions of dollars. The total spending in the race is estimated to be around $60 million.