A jury sentenced James E. Holmes to life in prison with no chance of parole on Friday, rejecting the death penalty for the man who carried out a 2012 shooting rampage that killed 12 people in a Colorado movie theater.

Since Mr. Holmes was convicted last month of more than 160 counts of murder and attempted murder, his lawyers and prosecutors have been putting questions of his fate before a jury of nine women and three men.

Prosecutors, emphasizing the human toll and indiscriminate cruelty of opening fire on a happy crowd of moviegoers, argued that he should join the three other men on Colorado’s death row. They argued that toll he exacted was so great, and the indiscriminate rampage so horrible, that death by lethal injection was the only just punishment.