For more than a decade, extremists have targeted Christians and other minorities, who often serve as stand-ins for the West. This was especially true in Iraq after the U.S. invasion, which caused hundreds of thousands to flee. ‘‘Since 2003, we’ve lost priests, bishops and more than 60 churches were bombed,’’ Bashar Warda, the Chaldean Catholic archbishop of Erbil, said. With the fall of Saddam Hussein, Christians began to leave Iraq in large numbers, and the population shrank to less than 500,000 today from as many as 1.5 million in 2003.

The Arab Spring only made things worse. As dictators like Mubarak in Egypt and Qaddafi in Libya were toppled, their longstanding protection of minorities also ended. Now, ISIS is looking to eradicate Christians and other minorities altogether. The group twists the early history of Christians in the region — their subjugation by the sword — to legitimize its millenarian enterprise. Recently, ISIS posted videos delineating the second-class status of Christians in the caliphate. Those unwilling to pay the jizya tax or to convert would be destroyed, the narrator warned, as the videos culminated in the now-­infamous scenes of Egyptian and Ethiopian Christians in Libya being marched onto the beach and beheaded, their blood running into the surf.

The future of Christianity in the region of its birth is now uncertain. ‘‘How much longer can we flee before we and other minorities become a story in a history book?’’ says Nuri Kino, a journalist and founder of the advocacy group Demand for Action. According to a Pew study, more Christians are now faced with religious persecution than at any time since their early history. ‘‘ISIL has put a spotlight on the issue,’’ says Anna Eshoo, a California Democrat in the U.S. House of Representatives, whose parents are from the region and who advocates on behalf of Eastern Christians. ‘‘Christianity is under an existential threat.’’