Both Republicans have been regularly engaged in pushing legislation on major issues — and both have made it a habit to form cross-chamber partnerships to further those endeavors.

But this particular partnership is notable given the high-profile nature of health care reform and that Rubio, Florida’s junior senator, and Ryan, the House Budget Committee chairman from Wisconsin, are both considered possible contenders for the Republican presidential nomination in 2016.

Aides to Rubio and Ryan declined to discuss the forthcoming proposal when asked about it Wednesday afternoon.

“Congressman Ryan continues working with his colleagues, including reformers like Sen. Rubio, on better solutions to deliver quality, affordable coverage to American families,” Ryan spokesman William Allison said.