According to the agency and many radiation experts, the dose is so low, even for children or cancer patients, that someone would have to pass through the machines more than a thousand times before approaching the annual limit set by radiation safety organizations.

But the letter to the White House science adviser, signed by five professors at University of California, San Francisco, and one at Arizona State University, points out several flaws in the tests. Studies published in scientific journals in the last few months have also cast doubt on the radiation dose and the machines’ ability to find explosives.

A number of scientists, including some who believe the radiation is trivial, say more testing should be done given the government’s plans to put millions of passengers through the machines. And they have been disturbed by the TSA’s reluctance to do so.

“There’s no real data on these machines, and in fact, the best guess of the dose is much, much higher than certainly what the public thinks,” said John Sedat, a professor emeritus in biochemistry and biophysics at UCSF and the primary author of the letter.