Who's ready for a new Rosie O'Donnell talk show?

Oprah Winfrey has turned over the hallowed “Oprah” studio to Rosie O’Donnell’s upcoming daytime show — hoping the loud-mouthed lightning-rod can be the savior of Winfrey’s struggling OWN cable network.

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O’Donnell’s weekday show, premiering this fall, will anchor OWN’s daytime lineup.

Rosie will move into Studio One — Oprah’s Chicago home for the last 25 years — shortly after Winfrey tapes the final episode of her legendary talk show, May 25.

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