The biggest differences in Osbourne’s genes compared to other people is how he processes drugs and booze.

Genes connected to addiction — alcoholism and the absorption of methamphetamines — all had unique variations in Osbourne, a few of which Knome geneticists had never seen before.

“He had a change on the regulatory region of the ADH4 gene, a gene associated with alcoholism, that we’ve never seen before,” Conde told ABC News. “He has an increased predisposition for alcohol dependence of something like six times higher.