Sen. John McCain has been receiving treatment for glioblastoma, an aggressive type of brain cancer, since last summer. Today, the McCain family issued a statement saying he had decided to discontinue further treatment.

“Last summer, Senator John McCain shared with Americans the news our family already knew: He had been diagnosed with an aggressive glioblastoma, and the prognosis was serious. In the year since, John has surpassed expectations for his survival. But the progress of disease and the inexorable advance of age render their verdict. With his usual strength of will, he has now chosen to discontinue medical treatment,” the statement says.

Meghan McCain posted the statement on Twitter along with her thanks for people’s prayers and support. “We could not have made it this far without you — you’ve given us the strength to carry on,” she wrote.

Cindy McCain also released this brief personal statement:

Here’s some initial reaction from Bret Baier at Fox News:

Jake Tapper is focusing on McCain’s own words:

Governor Doug Ducey of Arizona has issued a statement calling McCain an “American hero.”

Both Chuck Schumer and Mitch McConnell have made brief statements:

There are going to be hundreds of reactions on Twitter today but it’ll be interesting to see how President Trump responds. So far he hasn’t tweeted anything about the news.