“Piss Christ,” once branded as a “deplorable, despicable display of vulgarity,” will be displayed at the Edward Tyler Nahem Gallery in Manhattan on Thursday. The artwork features a “photograph of the crucifix submerged in the artist’s urine.”

The artwork debuted in 1989 and was funded through prize money provided by the National Endowment for the Arts. The art gallery hosting the retrospective salute to Andres Serrano is privately owned.

Religious groups and some lawmakers have already started sounding off – and making comparisons to the controversy over a recent anti-Muslim film. The low budget movie “Innocence of Muslims” sparked violent and deadly clashes across the globe.