“For whatever reason, [some] Republicans decided early on that this was a president they were just simply not going to cooperate with,” Holder said in a rare interview with ABC News’ Pierre Thomas. “And over the past five-and-a-half years, we have seen demonstrations of that, where the president has reached out his hand, offered compromises that have simply not been met [in the way] they have been in the past by a Republican Party willing to do the appropriate things.”

Administration efforts to pass comprehensive immigration reform, for example, have failed. Asked about calls by Sarah Palin to impeach Obama over the administration’s immigration policies, Holder said: “She wasn’t a particularly good vice presidential candidate. She’s an even worse judge of who ought to be impeached and why.”