Supporters and opponents of Egyptian leader Mohammed Morsi fought with rocks, firebombs and sticks outside the presidential palace in Cairo on Wednesday in large-scale clashes that marked the worst violence of a deepening crisis over the disputed constitution.

Egypt’s Health Ministry said 126 people were wounded in the clashes that were still raging hours after nightfall.

Three of Morsi’s aides resigned in protest of his handling of the crisis. With two aides who had quit earlier, now five of his panel of 17 advisers have left their jobs since the problems began.